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pentobarbital will reduce the extent or outcome of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital increases effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Watch. Coadministration of ifosfamide with CYP2B6 inducers might maximize metabolism of ifosfamide to its